Blog - Seven Bridges

May 8th, 2019

How Memoization Enhances Efficiency for Large Scale Genomic Analysis Research Projects

Memoization for large scale genomic analysis allows researchers and bioinformaticians to restart from a point of failure by enabling the reuse of existing outputs. This functionality is of critical importance given the size and complexity of genomic data and the impact of a failure on workflow efficiency and overall cost. …

Written by The Seven Bridges Computation Team

Automation

May 1st, 2019

How Computational Workflows for Genomic Analysis can be Simplified

Computational workflows are often not just computational workflows. Most interface with Library Information Management Systems (LIMS), Next-generation Sequencing (NGS) instruments, perform complex input validations, and coordinate processing between on-prem and cloud services. Many developers find that writing the code and software required to perform these integrations to be a daunting …

Written by Kaushik Ghose

Genomics

March 8th, 2019

BioCompute and Its Importance in Accelerating Market Access for New Drugs

The prevalence of NGS data within regulatory submissions has skyrocketed over the past few years which has prompted a collaboration amongst the Food and Drug Administration (FDA) and George Washington University to develop the BioCompute Object (BCO) as a standard for communicating NGS data. The BioCompute Object community aims to …

Written by Dennis Dean

Science

March 6th, 2019

Neoantigen Discovery Using Next-Generation Sequencing Data

Update (5/26/20) – Since originally publishing this post we’ve hosted a webinar on our Neoantigen Workflow. If you’d like an even deeper look at how to harness your NGS data, just click here! Leveraging neoantigens for guided treatment has become the definition of personalized cancer immunotherapy. Given their potential to …

Written by Vladimir Kovacevic

Useful Data

February 14th, 2019

Biomedical Datasets for Large Scale Analysis

Biomedical data is growing at astonishing rates with the broadening of access to next-generation sequencing (NGS) and single-cell solutions. Not only is more data being generated, but it is also being generated with improvements in base-calling accuracy, read length and the generation of reads from each end of the library …

Written by Manisha Ray

Graph Genome

January 31st, 2019

Pan-Genome Analysis Takes Center Stage

The concept of a pan-genome reference is straightforward: a reference structure that represents all the known genetic variation for a particular population or species. The representation of the human reference genome as a linear haploid DNA sequence poses limitations when trying to incorporate the known genetic diversity of human populations. …

Written by Devin Locke

Science

October 16th, 2018

Sentieon Multi-instance Whole Genome Workflow

Organizations have adopted the use of Next Generation Sequencing (NGS) as a one of the primary tools of their discovery, diagnostic and clinical efforts. Simultaneously — the number of tools available for NGS analysis has ballooned, with each tool having different capabilities for speed, accuracy, cost, etc. Seven Bridges offers …

Written by Vladimir Kovacevic, Ana Popic, Luka Topalovic, Milan Kovacevic, Aleksandar Minic, Stefan Risteski

Platform

July 25th, 2018

Data Cruncher Public Interactive Analyses

To help researchers transform raw NGS-based data into clinically actionable knowledge, Seven Bridges strives to efficiently bridge the gap between secondary and tertiary analysis. One of the features we offer to achieve this goal is Data Cruncher, which enables scientists to perform interactive computing and open-ended exploration of data on …

Written by Marko Milanovic, Nemanja Vucic, Milan Kovacevic, Boris Majic & Ana Damljanovic

Genomics

June 12th, 2018

Taxanomic Profiling of Metagenomics Samples

Numerous colonies of different organisms live virtually everywhere on Earth, even in and on our bodies. They are called microbes and we think we know all about them. But do we really? Actually, the human race knew nothing about microbes before the 17th century. There were some assumptions and hypotheses, …

Written by Aleksandar Danicic, Nemanja Vucic, Srdjan Kasapovic and Vesna Pajic